Health experts clash over use of certain drugs for COVID-19

Health experts clash over use of certain drugs for COVID-19 Health officials around the world are clashing over the use of certain drugs for COVID-19, leading to different treatment options for patients depending on where they live. On Friday, a... AP NEWS

Health officials around the world are clashing over the use of certain drugs for COVID-19, leading to different treatment options for patients depending on where they live.

On Friday, a World Health Organization guidelines panel advised against using the antiviral remdesivir for hospitalized patients, saying there’s no evidence it improves survival or avoids the need for breathing machines.

But in the U.S. and many other countries, the drug has been the standard of care since a major, government-led study found other benefits — it shortened recovery time for hospitalized patients by five days on average, from 15 days to 10.

Within the U.S., a federal guidelines panel and some leading medical groups have not endorsed two other therapies the Food and Drug Administration authorized for emergency use -- Eli Lilly’s experimental antibody drug and convalescent plasma, the blood of COVID-19 survivors. The groups say there isn’t enough evidence to recommend for or against them.

Doctors also remain uncertain about when and when not to use the only drugs known to improve survival for the sickest COVID-19 patients: dexamethasone or similar steroids.

And things got murkier with Thursday’s news that the anti-inflammatory drug tocilizumab may help. Like the key WHO study on remdesivir, the preliminary results on tocilizumab have not yet been published or fully reviewed by independent scientists, leaving doctors unclear about what to do.

“It’s a genuine quandary,” said the University of Pittsburgh’s Dr. Derek Angus, who is involved in a study testing many of these treatments. “We need to see the details.”

Dr. Rochelle Walensky, infectious disease chief at Massachusetts General Hospital, agreed.

“It’s really hard to practice medicine by press release,” she said on a podcast Thursday with a medical journal editor. Until the National Institutes of Health’s guidelines endorse a treatment, “I’m really reluctant ... to call that standard of care.”

Angus said there are legitimate questions about all of the drug studies.

“It’s not unusual for professional guidelines to disagree with each other, it’s just that it’s all under the microscope with COVID-19,” he said.

The rift over remdesivir, sold as Veklury, by Gilead Sciences Inc., is the most serious. The WHO guidelines stress that the drug does not save lives, based heavily on a WHO-sponsored study that was larger but much less rigorous than the U.S.-led one that found it had other benefits. ......